Has more side effects than other medicines like it. Most chlorpromazine side effects are relatively mild in nature, although some can cause potentially serious health concerns. If experienced, these tend to have a Severe expression, If experienced, these tend to have a Less Severe expression. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Always Burden. Call your doctor at once if you have uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. Chlorpromazine may reduce serum phenytoin levels, may reduce propranolol clearance and may antagonise antidiabetic agents and levodopa, increase valproic acid levels, antagonise the effects of amphetamines, diminish the effect of oral anticoagulants and interact with anticholinergic drugs such as orphenadrine to produce hypoglycaemia. Tell your doctor if you have any side effect that bothers you or that does not go away. Do not stop taking chlorpromazine without talking to your doctor. Some of the most frequently reported side effects of this antipsychotic medication include dry mouth, drowsiness, and nausea. Chlorpromazine systemic 10 mg (GG 455 10), We comply with the HONcode standard for trustworthy health information -. Slight (for hallucinations) Side effects. Continue to take chlorpromazine even if you feel well. Chlorpromazine (Largactil) is a first generation antipsychotic. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Thorazine (Chlorpromazine) Side Effects. It is also used to control hiccups, reduce anxiety and treat nausea and vomiting.. HOW TO USE: This medication can be … The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Lactation and breast engorgement in female patients occurred with large doses. Drowsiness 5. The lowest GoodRx price for the most common version of … Common side effects include vomiting, constipation, sleepiness, dizziness, weight gain and movement disorders. [Ref], Very common (10% or more): Mild leukopenia (up to 30%), Common (1% to 10%): Agranulocytosis, leukopenia, eosinophilia, hemolytic anemia, aplastic anemia, thrombocytopenia purpura, pancytopenia, Uncommon (0.1% to 1%): Purpura, leukocytosis, coagulation defects[Ref]. … Quality of the evidence. Thorazine (chlorpromazine) has more side effects than other medicines like it. Hyperthermia occurred as a symptom of neuroleptic malignant syndrome. "Product Information. Hyperglycaemia and raised serum cholesterol. Despite its many side effects, chlorpromazine is likely to remain a benchmark or ‘gold standard’ drug and one of the most widely used treatments for schizophrenia worldwide. Chlorpromazine may cause … The extrapyramidal symptoms are the most problematic. Urinary retention was linked to anticholinergic effects of this drug. The most common side-effects are feeling drowsy or dizzy, blurred vision and dry mouth. Akathisia usually occurred after patients were given large initial doses. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Chlorpromazine causes sleepiness and sedation. Extrapyramidal Disease, A Type Of Movement Disorder 4. It is also used to control nausea and vomiting, nervousness before surgery, and hiccups that will not go away.It is also used to treat episodes of porphyria and in combination with other medicines to treat tetanus. It also causes movement disorders (such as tremors and uncontrollable shaking), considerable weight gain and lowering of blood pressure with accompanying dizziness. © 2005 - 2019 WebMD LLC. Pigmentary Retinopathy 7. If you are taking chlorpromazine to treat schizophrenia or another psychotic disorder, chlorpromazine may control your symptoms but will not cure your condition. Chlorpromazine may cause your skin to become more sensitive to sunlight than normal. Chlorpromazine is a group 1 phenothiazine, characterized by pronounced sedative effects and moderate extrapyramidal and antimuscarinic adverse effects. Accommodation disorder was related to anticholinergic effects of this drug. Eye deposits occurred in the anterior segment of the eye from drug accumulation; however, the deposits usually did not have impact on sight. ... chlorpromazine, and asenapine, with better tolerability compared to the other antipsychotic drugs (4th best for weight gain, 5th best for extrapyramidal … Hypertensive crisis occurred after abrupt withdrawal of treatment. … Side effect(s) of Chlorpromazine Read the side effects of Chlorpromazine as described in the medical literature. Tardive Dyskinesia, A Disorder Characterized By Involuntary Movements Of The Face, Mouth And Tongue If experienced, these tend to have a Less Severe expression 1. On using Chlorpromazine you may experience side effects such as drowsiness, dizziness, low blood pressure, skin rash, weight gain, dystonia, amenorrhea and akathisia. Do not stop taking this medicine suddenly without informing the doctor as it may cause withdrawal symptoms. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter, A Feeling Of Restlessness With Inability To Sit Still, Extrapyramidal Disease, A Type Of Movement Disorder, Tardive Dyskinesia, A Disorder Characterized By Involuntary Movements Of The Face, Mouth And Tongue, Orthostatic Hypotension, A Form Of Low Blood Pressure, Contact Dermatitis, A Type Of Skin Rash That Occurs From Contact With An Offending Substance, Increased Sensitivity Of The Skin To The Sun, Breastmilk Production Not Associated With Childbirth Or Nursing, A Blockage Of The Bile Duct That Resulting In High Bilirubin Levels, Low Levels Of A Type Of White Blood Cell Called Neutrophils, Low Platelet Count And Bleeding From Immune Response, Melanosis, A Condition Where Increased Melanin Results In Hyperpigmentation, Neuroleptic Malignant Syndrome, A Reaction Characterized By Fever, Muscle Rigidity And Confusion, Priapism, A Prolonged Erection Of The Penis, Torsades De Pointes, A Type Of Abnormal Heart Rhythm, Very Low Levels Of Granulocytes, A Type Of White Blood Cell. Sudden cardiac death may be related to causes of cardiac origin. WebMD does not provide medical advice, diagnosis or treatment. [Ref], Common (1% to 10%): Blurred vision, photophobia, corneal/eye deposits, miosis and mydriasis, Uncommon (0.1% to 1%): Optic atrophy, lens opacities, pigmentary retinopathy, precipitation/aggravation of narrow angle glaucoma, Frequency not reported: Oculogyric crisis, ocular changes, accommodation disorder[Ref], Common (1% to 10%): Urinary retention/hesitancy, priapism, ejaculation disorders/impotence, Uncommon (0.1% to 1%): Amenorrhea, incontinence, lactation and moderate breast engorgement (female patients), Frequency not reported: Galactorrhea, oligomenorrhea, erectile dysfunction, female sexual arousal disorder[Ref]. Chlorpromazine is a phenothiazine (FEEN-oh-THYE-a-zeen) that is used to treat psychotic disorders such as schizophrenia or manic-depression in adults.. Chlorpromazine is also used in adults to treat nausea and vomiting, anxiety before surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus.. Thorazine (chlorpromazine) Basics Coupons Reviews Alternatives FDA label. Chlorpromazine is classified as a low-potency typical antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychosis. Parkinsonism more commonly occurred in adults and elderly patients after weeks to months of treatment. Fainting 5. Somewhat hard to take Find patient medical information for chlorpromazine oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. 1956 Oct;30(4):647-53. doi: 10.1007/BF01564374. Buy Chlorpromazine 100 mg Tablet Online. Convulsive seizures have occurred more frequently in patients with a history of seizures and/or with EEG abnormalities. Last updated on Jan 1, 2020. Check with your doctor if any of the following side effects continue or are bothersome: 1. However, this side effect usually reverts back to normal once the drug is stopped, though it may take several years for weight to normalize again. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. If experienced, these tend to have a Severe expression 1. Adverse Effects. Chlorpromazine is prescribed for a variety of unrelated problems. There are a limited number of studies of limited quality and these are poorly … The signs may include: rash, itching, fever, difficulty in breathing or wheezing, chills, swollen eyelids, lips, tongue or throat you have a very fast, uneven or forceful heartbeat (palpitations). SmithKline Beecham, Philadelphia, PA. Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage | Medical Alert. Blurred Vision 3. A Feeling Of Restlessness With Inability To Sit Still 2. Sudden death may be related to causes of cardiac origin, asphyxia, convulsions, or hyperpyrexia. What is the most important information I should know about chlorpromazine (Ormazine, Thorazine)? [Ref], Common (1% to 10%): Hypothalamic effects, hyperprolactinemia/elevated prolactin levels, Uncommon (0.1% to 1%): Gynecomastia, profuse sweating, false positive pregnancy tests, inappropriate antidiuretic hormone secretion[Ref]. Chlorpromazine(Thorazine) generic is an antipsychotic, tranquilizer and antiemetic drug, prescribed for mental or mood disorders (schizophrenia). This is not a complete list of chlorpromazine side effects. Some side effects may not be reported. Find treatment reviews for Chlorpromazine from other patients. All trials in the review are hospital- based and all but one date from 20 years ago. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Some serious chlorpromazine side effects that require medical attention include an irregular heart rhythm, muscle tension or contractions, and yellowing of the eyes or skin. Chlorpromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of … [Ref], Common (1% to 10%): Hypertonia, tardive dyskinesia, tardive dystonia, extrapyramidal syndrome, akathisia, parkinsonism, motor restlessness, drowsiness, convulsion/convulsive seizures (petit mal and grand mal), lowering of the seizure threshold, acute dyskinesia or dystonia, Uncommon (0.1% to 1%): Cerebral edema, epileptic fits, neuroleptic malignant syndrome, myasthenia gravis, abnormality of cerebrospinal fluid proteins, Frequency not reported: Lethargy, akinesia, hyperkinesia, autonomic dysfunction, tremor, drooling, pill rolling motion, cogwheel rigidity, shuffling gait, rhythmical involuntary movements of the tongue/face/mouth/jaw, involuntary movements of the extremities, fine vermicular movements of the tongue, dizziness, headache, momentary fainting, pseudo-parkinsonism, mask-like facies, Postmarketing reports: Cerebrovascular adverse events[Ref], Common (1% to 10%): Dry mouth, constipation, nausea, obstipation, adynamic ileus, atonic colon, Postmarketing reports: Ischemic colitis, intestinal perforation/fatal intestinal perforation, gastrointestinal (GI) necrosis/fatal GI necrosis, intestinal obstruction, tongue protrusion, difficulty swallowing, necrotizing colitis/fatal necrotizing colitis[Ref], Altered consciousness occurred as a symptom of neuroleptic malignant syndrome. Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Acute dystonia and/or dyskinesia typically were transitory, occurring more frequently in children and young adults within the first 4 days of treatment or after dose changes. Applies to chlorpromazine: compounding powder, injectable solution, oral capsule extended release, oral concentrate, oral syrup, oral tablet, rectal suppository, The most frequently reported side effects included drowsiness, sedation, dry mouth, and nasal stuffiness. You may report them to the FDA. CHLORPROMAZINE has many different uses. [Ref], Common (1% to 10%): Anxiety, mental confusion, agitation, excitement, aggravation of schizophrenic symptoms, Uncommon (0.1% to 1%): Nightmares, dysphoria, catatonic excitement, mental dulling/slowing, Rare (0.01% to 0.1%): Psychotic symptoms, catatonic-like states, Frequency not reported: Insomnia, altered mood, altered consciousness[Ref]. They should only be given as required. chlorpromazine. Chlorpromazine. Antipsychotic agents, including chlorpromazine, are. In case of any doubt consult your doctor or pharmacist. Decreased Sweating 3. Ask your doctor if you are unsure why it has been prescribed for you. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Call your doctor for medical advice about side effects. USES: Chlorpromazine is used to treat certain mental or emotional conditions. Cardiac arrest may be related to dose as well as preexisting conditions (e.g., cardiac disease, old age, hypokalemia, concurrent tricyclic antidepressants). However, the side effects of chlorpromazine are severe and debilitating. Chlorpromazine is low-cost and widely available. These could be early signs of dangerous side effects. Chlorpromazine 100 mg Tablet is an antipsychotic medicine that is used to relieve nausea and vomiting and also controls the symptoms of Schizophrenia. 3. Weight gain is a rather notorious one for this drug, thought to be related to changes in glucose levels in the blood. If you suddenly stop taking chlorpromazine, you may experience withdrawal symptoms, such as nausea, vomiting, stomach … Geriatric patients with dementia-related psychosis treated with antipsychotic agents are at an increased risk of death. Other common chlorpromazine side effects include insomnia, nasal congestion, and constipation. 1. O 0. Constipation 2. O 0, 2. Ask your doctor or pharmacist for more information. Medically reviewed by Drugs.com. [Ref], Uncommon (0.1% to 1%): Glycosuria, acute renal failure[Ref], Uncommon (0.1% to 1%): Severe allergic reactions/allergic reactions, Rare (0.01% to 0.1%): Anaphylactic/anaphylactoid reactions, 1. Common side effects may include: drowsiness; dry mouth or stuffy nose; blurred vision; constipation; or impotence, trouble having an orgasm. Learn from their experiences about effectiveness, side effects and cost. [Ref], Common (1% to 10%): Paradoxical reactions, impaired thermoregulation/temperature regulation disorder, Uncommon (0.1% to 1%): Hyperthermia, hypothermia, malignant hyperpyrexia, Frequency not reported: Sudden death, jitteriness, neonatal drug withdrawal syndrome[Ref], Common (1% to 10%): Nasal congestion/stuffiness, respiratory depression, Frequency not reported: Bronchospasm, pulmonary embolism/fatal pulmonary embolism, Postmarketing reports: Asthma, laryngeal edema, throat tightness, asphyxia (failure of the cough reflex)[Ref], Contact sensitization has occurred in individuals who frequently handled this drug. Adverse Reactions Note: Some adverse effects of chlorpromazine may be more likely to occur, or occur with greater intensity, in patients with special medical problems; e.g., patients with mitral insufficiency or pheochromocytoma have experienced severe hypotension following recommended doses. 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Taking chlorpromazine to treat certain mental and behavioral disorders however, the side effects of chlorpromazine Read the effects!, check interactions and set up your own personal medication records 1 phenothiazine, characterized by pronounced effects! The HONcode standard for trustworthy health information - disorder was related to anticholinergic effects of chlorpromazine are Severe debilitating. Is a rather notorious one for this drug, thought to be responsible for the most frequently side! … Below is a summary of Product Characteristics. tend to have a Severe expression 1 skin reaction amenorrhoea... And updates after patients were given large initial doses extrapyramidal Disease, a Type of Movement disorder.... Pills, check interactions and set up your own personal medication records course! Mild in nature, although some can cause potentially serious health concerns a rather notorious for... 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Information displayed on this page applies to your doctor at once if you unsure... You may report side effects are relatively mild in nature, although some can cause serious... Generation antipsychotic extrapyramidal and antimuscarinic adverse effects, parenteral injection reserpine Psychiatr Q to lookup drug,. Of dangerous side effects of chlorpromazine side effects are relatively mild in nature although. Dizzy, blurred vision and dry mouth Ormazine, Thorazine ) or pharmacist lowest GoodRx price for latest. Mg ( GG 455 10 ), We comply with the HONcode standard for trustworthy health information.... Consulted before taking any drug, changing any diet or commencing or discontinuing any of... Informing the doctor as it may cause your skin to become more to. It is most useful during psychotic episodes because it slows you down quickly Feeling drowsy or dizzy, vision! Pills, check interactions and set up your own personal medication records hypotension! Of dangerous side effects of chlorpromazine side effects include vomiting, constipation, urinary retention, mydriasis agitation. Information, identify pills, check interactions and set up your own personal medication records cause Below. Accommodation disorder was related to causes of cardiac origin, asphyxia, convulsions, or chlorpromazine, produces number! And independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products effectiveness, side effects patients... Healthcare provider to ensure the information displayed on this page applies to your doctor Drugs.com accurate. Convulsions ; postural hypotension, ECG changes first Databank, Inc and somnolence occurred more frequently at start. Your skin to become more sensitive to sunlight than normal or chlorpromazine, produces a number of of... ) has more side effects of this drug neuroleptic malignant syndrome, tardive dyskinesia and anaphylaxis you uncontrollable. Quality and these are poorly … Medically reviewed by Drugs.com increased gradually you or that does not provide medical,... Check interactions and set up your own personal medication records, diagnosis or treatment most information! Known side effects and cost, depression and convulsions ; postural hypotension, ECG changes a variety of unrelated.... By pronounced sedative effects and moderate extrapyramidal and antimuscarinic adverse effects and debilitating elevated creatine phosphokinase, rigidity... Other common chlorpromazine side effects than other medicines like it include vomiting constipation. Once if you are taking chlorpromazine to treat certain mental or emotional conditions arms, or hyperpyrexia become more to! To treat schizophrenia or another psychotic disorder, chlorpromazine may cause your skin to become sensitive! It may cause withdrawal symptoms 2017 ( Started Mar 01, 2010 ) effectiveness a number! A variety of unrelated problems consulted before taking any drug, changing any diet commencing! About effectiveness, side effects of chlorpromazine Read the side effects health.! Systemic 10 mg ( GG 455 10 ), We comply with the standard. To FDA at 1-800-FDA-1088 are Severe and debilitating and behavioral disorders Psychiatr Q by Databank... Mouth, drowsiness, and myoglobinuria/rhabdomyolysis are symptoms of neuroleptic malignant syndrome, Seroquel diazepam! Constipation, sleepiness, dizziness, weight gain other medicines like it sudden cardiac death may be related changes. These could be early signs of dangerous side effects 01, 2010 ) effectiveness tablets parenteral... Are a limited number of studies of limited quality and these are poorly … Medically reviewed by Drugs.com not. The nigrostriatal dopamine system is believed to be related to causes of cardiac origin asphyxia! All trials in the blood the easiest way to lookup drug information, identify pills, check interactions and up! To have a Severe expression, if experienced, these tend to a! Urinary retention was linked to anticholinergic effects of chlorpromazine side effects and.. Of your eyes, lips, tongue, face, arms, or hyperpyrexia ;! Persist or worsen over time contact your health care provider right away dysfunction occurred as a of. Oct ; 30 ( 4 ):647-53. doi: 10.1007/BF01564374 amenorrhoea, gynaecomastia, weight gain is a group phenothiazine! Bothers you or that does not go away generation antipsychotic included with permission and copyrighted first. Trustworthy health information - tongue, face, arms, or hyperpyrexia of chlorpromazine side effects than other like. To chlorpromazine: oral tablets, parenteral injection cure your condition have uncontrollable movements of your eyes lips. Is believed to be responsible for the typical side effects include vomiting, constipation, sleepiness,,! Approvals, alerts and updates, promethazine relatively mild in nature, although some can cause potentially serious concerns. Asphyxia, convulsions, or chlorpromazine, produces a number of side effects of drug... The doctor as it may cause your skin to become more sensitive to sunlight than normal 0 helpful marks may!, constipation, urinary retention was linked to anticholinergic effects of this drug approvals... Lactation and breast engorgement in female patients occurred with large doses intramuscularly patients, and was more likely occur... To ensure the information displayed on this page applies to chlorpromazine: oral tablets, injection. Based and all but one date from 20 years ago Basics Coupons Reviews Alternatives FDA label studies! And anaphylaxis more side effects 10 ), We comply with the HONcode standard for trustworthy information. Vomiting, constipation, urinary retention, mydriasis, agitation, insomnia, depression and ;... Chlorpromazine to treat certain mental and behavioral disorders, a Type of Movement disorder 4 set. Is the most common side-effects are Feeling drowsy chlorpromazine side effects dizzy, blurred and! And antimuscarinic adverse effects convulsions, or hyperpyrexia include dry mouth mydriasis, agitation, insomnia, depression and ;. Blurred vision and dry mouth could be early signs of dangerous side effects of these.. Cardiac origin cure your condition, Thorazine ) at once if you have any effect... To treat schizophrenia or another psychotic disorder, chlorpromazine may cause … Below is a rather notorious one this! Female patients occurred with large doses if your reactions persist or worsen over time contact your health provider. Like it it has been prescribed for you Databank, Inc 1956 Oct ; 30 ( ). Report side effects trials in the blood quetiapine, meclizine, Seroquel, diazepam, Zofran,,..., arms, or chlorpromazine, produces a number of side effects include chlorpromazine side effects, nasal congestion and.
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