As a result of the inadequate documentation, this study cannot be included in the evaluation. There are no data available in vivo for the genotoxicity of diethylene glycol monobutyl ether acetate. “Diethylene glycol monobutyl ether” 2008). “Diethylene glycol monobutyl ether” 2008). However, ready absorption after inhalation exposure is assumed in analogy to other glycol ethers and glycol acetates (Lundberg 1995). Working off-campus? A study, that was not available to the OECD in the original but only as a summary, reported slight irritation of rabbit skin after exposure to diethylene glycol monobutyl ether acetate (OECD 2005). A wide variety of diethylene glycol monobutyl ether acetate c10h20o4 options are available to you, such as grade … Several studies were carried out to investigate the effects of diethylene glycol monobutyl ether on offspring after ingestion and dermal application, but no evidence of prenatal or postnatal toxicity was found up to the highest doses tested: in rats, after the administration of diethylene glycol monobutyl ether with the diet on days 1 to 21 of gestation in doses of up to 633 mg/kg body weight and day with prenatal and postnatal examinations and after 13‐week dermal application of 2000 mg/kg body weight and day; in mice, after the oral administration of up to 2050 mg/kg body weight and day on days 6 to 13 of gestation, and in rabbits after the dermal application of up to 1000 mg/kg body weight and day on days 7 to 18 of gestation and prenatal examination (see Floats and mixes slowly with water. The application of 0.5 ml undiluted diethylene glycol monobutyl ether acetate produced slight damage to the rabbit eye after 24 hours (no other details) (Carpenter and Smyth 1946). Alibaba.com offers 790 diethylene glycol monobutyl ether acetate c10h20o4 products. Use the link below to share a full-text version of this article with your friends and colleagues. Diamond Hazard Value Description; 1 1 0 Health 1: Can cause significant irritation. Metabolites of diethylene glycol monobutyl ether acetate. Eastman™ DB Acetate is especially useful in screen inks and as a retarder solvent in coil coatings. There are no studies available specifically for diethylene glycol monobutyl ether acetate. The penetration of undiluted and diluted diethylene glycol monobutyl ether acetate through the skin can be compared quantitatively with that of diethylene glycol monobutyl ether and other glycol ethers. 11 octanol/water partition coefficient. Up to concentrations of 15 ml/m3, diethylene glycol monobutyl ether acetate, like diethylene glycol monobutyl ether, is therefore probably present as a vapour. The metabolites were determined in the urine. Diethylene glycol monobutyl ether (DEGBE) is produced by the reaction of ethylene oxide and n-butanol with an alkalic catalyst. In the high dose group, the calculated dermal penetration rate of diethylene glycol monobutyl ether acetate was 1.58 and 1.28 mg/cm2 and hour in male and female rats, respectively. (2011) Diethylene Glycol Monobutyl Ether Acetate. It is used primarily as a coalescing aid in latex paints and as a … Flammable and/or toxic … Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). A no adverse effect concentration of 14 ml/m3 (about 100 mg/m3) was obtained from the inhalation studies with rats. From Wikipedia, the free encyclopedia Diethylene glycol (DEG) is an organic compound with the formula (HOCH 2 CH 2) 2 O. After 1 year without exposure to diethylene glycol monobutyl ether or its acetate and with healed dermatitis, the worker did not react to diethylene glycol monobutyl ether acetate in a renewed patch test (no other details) after occlusive treatment, but reacted to the application of 0.1 ml diethylene glycol monobutyl ether acetate or diethylene glycol monobutyl ether in a test after 20 minutes of non‐occlusive treatment (Dawson et al. Package Of Diethylene Glycol Monobutyl Ether Acetate… All rights reserved. This corresponds to a mean absorption rate of 1.36 mg/cm2 and hour. DB Acetate (Diethylene Glycol Monobutyl Ether Acetate). As used herein, ® denotes registered trademark status in the U.S. only. There are no carcinogenicity studies available for either diethylene glycol monobutyl ether acetate or diethylene glycol monobutyl ether. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, By continuing to browse this site, you agree to its use of cookies as described in our, I have read and accept the Wiley Online Library Terms and Conditions of Use, Toxicology of diethylene glycol butyl ether 2. … Diethylene glycol monobutyl ether yielded negative results in a maximization test in guinea pigs. Cite this entry as: Gooch J.W. There are no data available for the carcinogenicity of diethylene glycol monobutyl ether acetate. Learn more. There are no data available for the developmental toxicity of diethylene glycol monobutyl ether acetate. If the skin was washed 5 minutes after the application of 200 mg/kg body weight, up to 89% of the radioactivity could be washed off (Boatman et al. Also Peak Limitation Category I with an excursion factor of 1.5 has provisionally been established for diethylene glycol monobutyl ether acetate in analogy to diethylene glycol monobutyl ether. After 72 hours, 4% of the radioactivity was still present in the body (Deisinger and Guest 1989). Nor was diethylene glycol monobutyl ether found to have any mutagenic effects in the available studies (see In a study with male and female Sprague‐Dawley rats with dermal application of radioactively labelled diethylene glycol monobutyl ether in doses of 200 or 2000 mg/kg body weight or as a 10% aqueous solution, 2‐(2‐butoxyethoxy)acetic acid was the major urinary metabolite with 60% to 80% of the radioactivity. Di(2-ethylhexyl) azelate. Learn about our remote access options. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). Diethylenetriamine. Browse other articles of this reference work: The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Diethylene glycol monoricinoleate. There are no studies available with long-term administration of diethylene glycol monobutyl … Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). The available studies do not provide any evidence of genotoxicity for diethylene glycol monobutyl ether. The LD50 after the ingestion of diethylene glycol monobutyl ether acetate was 11 920 mg/kg body weight. However, suitable studies should be carried out with diethylene glycol monobutyl ether acetate to validate these values. The MarketWatch News Department was not involved in the creation of this content. Diethylene glycol monobutyl ether acetate was not found to have mutagenic potential in studies with Salmonella typhimurium. Diethylene Glycol Monobutyl Ether Acetate 124-17-4,Can be used as preparation agent of printing ink_OKCHEM Please note that all emails sent by OKCHEM are from ***@okchem.com, service@mail. It has application as a selective solvent in the separation of alcohols and ketones by distillation. No NOAEL (no observed adverse effect level) or LOAEL (lowest observed adverse effect level) was obtained in this study. In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate is not classified in any of the categories for carcinogens or germ cell mutagens. In a 13‐week study in which diethylene glycol monobutyl ether was administered to rats with the drinking water, no histopathological changes to the sexual organs were detected up to the highest dose used of 1000 mg/kg body weight and day (see Diethylene glycol monobutyl ether had no effect on the offspring of rats given oral doses of up to 633 mg/kg body weight and day, or of rats treated dermally with up to 2000 mg/kg body weight and day, or of rabbits given up to 1000 mg/kg body weight and day (see 111-76-2: Diethylene Glycol Monoethyl Ether : Carbitol cellosolve. Several studies were carried out with repeated inhalation, ingestion and … After deacetylation, only a small amount of diethylene glycol monobutyl ether acetate is metabolized by alcohol dehydrogenase, while the major part is metabolized by cytochrome P450 enzymes. Ethylene glycol monoethyl ether acetate: Ethyl cellosolve acetate. and you may need to create a new Wiley Online Library account. If you do not receive an email within 10 minutes, your email address may not be registered, As a result of the inadequate documentation, this study cannot be included in the evaluation. In another study, an absorption rate of 0.035 mg/cm2 and hour was determined for human skin (OECD 2005). Packaging 1, 4 … Eastman™ DB Acetate (Diethylene Glycol Monobutyl Ether Acetate) is a high boiling glycol ether ester widely used in printing inks, high-bake enamels, and as a coalescing aid in low pH latex paints. Several studies were carried out with repeated inhalation, ingestion and dermal application of diethylene glycol monobutyl ether. Ethanol, 2‐(2‐butoxyethoxy)‐, acetate [CAS Nr. “Diethylene glycol monobutyl ether” 2008). No histological changes were observed in the reproductive organs (OECD 2005). Diethylene glycol monobutyl ether acetate is rapidly absorbed after ingestion and eliminated mainly with the urine. The ether being relatively unreactive. Diethylene glycol monobutyl ether acetate. The LD50 for mice was 6468 mg/kg body weight and for guinea pigs 2340 mg/kg body weight. Diethylene glycol monobutyl ether acetate caused slight to moderate irritation of the rabbit eye (OECD 2005). © 2021 Eastman Chemical Company or its subsidiaries. In vitro studies with rat blood showed that 5 mM diethylene glycol monobutyl ether acetate was rapidly hydrolyzed to diethylene glycol monobutyl ether by esterases present in the blood. ETHYLENE GLYCOL MONOBUTYL ETHER ACETATE is incompatible with the following: Oxidizers (NIOSH, 2016). There are no data available for the effects of diethylene glycol monobutyl ether acetate after inhalation. Laboured breathing, reduced activity, increased respiratory rate, anorexia, weakness, tremor and straightened posture were observed in the animals at the high doses (OECD 2005). The LC50 after the exposure of rats (no other details) to diethylene glycol monobutyl ether acetate for 4 hours was 8696 ml/m3. The application segment for diethylene glycol … Diethylene glycol monobutyl ether had no effect on the mating index, pregnancy incidence or male and female fertility indices after dermal application of 2000 mg/kg body weight and day for 13 weeks. After single oral doses of radioactively labelled diethylene glycol monobutyl ether acetate of 200 or 2000 mg/kg body weight, male Sprague Dawley rats exhaled about 5% of the administered radioactive dose as 14CO2. Diethylene glycol butyl ether is a high boiling solvent, which can be used in coating industry. On the basis of the available data and by analogy with diethylene glycol monobutyl ether, dermal exposure is assumed to pose no additional risk. Flammable and/or toxic gases are generated by the combination of alcohols with alkali … 1999. At least the glycine conjugate can be ruled out as an impurity and must have been formed during metabolism. Oral administration of diethylene glycol monobutyl ether in doses of 1000 mg/kg body weight and day and above over a period of 13 weeks caused increased liver weights, a reduced number of red blood cells and changes in some protein concentrations in the blood and enzyme activities in the liver of rats. In 13‐week studies with rats exposed to diethylene glycol monobutyl ether, a NOAEL of 50 mg/kg body weight and day was obtained after oral administration and a NOAEL of 2000 mg/kg body weight and day after dermal application. There are also no valid data for the repeated uptake of diethylene glycol monobutyl ether acetate in animals. A worker who had been exposed to diethylene glycol monobutyl ether acetate and diethylene glycol monobutyl ether and had developed acute dermatitis on his hands, arms, face and neck reacted strongly to undiluted diethylene glycol monobutyl ether acetate in a patch test after 48 and 72 hours. DIETHYLENE GLYCOL MONOBUTYL ETHER ACETATE; NFPA 704. An LD50 of 1956 mg/kg body weight and day was reported. It is an ether-ester derivative. During the first 8 hours, 59% of the low dose and 42% of the high dose were eliminated with the urine. DIETHYLENE GLYCOL MONOBUTYL ETHER ACETATE: ICSC: 0789: 2-(2-Butoxyethoxy)ethanol acetate Butyl carbitol acetate Diglycol monobutyl ether acetate DEGBEA: April 2004 Synonym: Butyldiglycol acetate, Diethylene glycol monobutyl ether acetate Linear Formula: CH 3 COOCH 2 CH 2 OCH 2 CH 2 O(CH 2 ) 3 CH 3 Molecular Weight: 204.26 Diethylene glycol monobutyl ether is absorbed dermally only to a small extent and is not sensitizing. This documentation is based mainly on a review of the data for diethylene glycol monobutyl ether acetate carried out under the OECD‐ICCA programme (OECD 2005). Diethylene glycol monobutyl ether acetate agent detailed information in Haz-Map database. There are no data available for the effects after the ingestion of diethylene glycol monobutyl ether acetate. Diethyl ether. Diethylene glycol monobutyl ether acetate has therefore not been designated with an “H”. Diethylene glycol monobutyl ether acetate is a colorless liquid with a mild odor. Flammability 1: Must be preheated before ignition can … Studies with Salmonella typhimurium and Escherichia coli WP2uvrA yielded no evidence that diethylene glycol monobutyl ether acetate has mutagenic potential. Eastman™ DB Acetate … In Alaska, frequent treatment of a 3‐year‐old child with an insect repellent containing 50% diethylene glycol monobutyl ether acetate, 15% diethylene glycol ethyl ether and 28% ethanol during one summer led to nephrosis (Lundberg 1995). After 24‐hour occlusive application of radioactively labelled diethylene glycol monobutyl ether acetate in doses of 2000 mg/kg body weight or of a 10% aqueous solution of 200 mg/kg body weight to the dorsal skin of 4 male or 4 female Sprague Dawley rats, up to 88% of the radioactivity was recovered within 24 hours in the urine and faeces and when the animals and cages were washed. Diethylene Glycol Monobutyl Ether Acetate is a important solvent, used for ink, paint and coating industry. After 10‐minute incubation, a plateau concentration of about 6% of the initial concentration was reached, which remained constant for about 14 minutes (OECD 2005). CAS: 124-17-4: Molecular Formula: C10H20O4: Molecular Weight (g/mol) 204.266: MDL Number: MFCD00009458: InChI Key: VXQBJTKSVGFQOL-UHFFFAOYSA-N: Synonym: 2-2-butoxyethoxy ethyl acetate,butoxyethoxyethyl acetate,diethylene glycol monobutyl ether acetate,butyl diglycol acetate,butyl carbitol acetate,ektasolve db acetate,2-2-butoxyethoxy ethanol acetate,butyl diethylene glycol acetate … Diethylene Glycol Monobutyl Ether Acetate Market is a … … Eastman™ DB Acetate (Diethylene Glycol Monobutyl Ether Acetate) is a high boiling glycol ether ester widely used in printing inks, high-bake enamels, and as a coalescing aid in low pH latex paints. 1989). In vitro studies yielded a mean permeability constant of 1.38×10‐3 cm rat skin per hour for diethylene glycol monobutyl ether acetate. In addition, diethylene glycol accounted for 12% of the radioactivity, a non‐quantified fraction was ethylene glycol and 32% was detected in 2‐(2‐(3‐ or 4‐hydroxybutoxy)ethoxy)ethanol. Please enable scripts and reload this page. The market for diethylene glycol monobutyl ether acetate will reach an estimated value of USD 176.84 million by … In an inadequately documented study from 1944, diethylene glycol monobutyl ether acetate was applied to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. Diethylene glycol monobutyl ether acetate market is segmented in terms of market value, volume, market opportunities, and niches into multiple applications. In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate has not been designated with “Sa” or “Sh”. In diffusion cell experiments with excised human skin, a flux of 59±36.2 µg/cm2 and hour was calculated for undiluted diethylene glycol monobutyl ether acetate. Diethylene glycol monobutyl ether acetate is therefore not suspected of having genotoxic effects. DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. There are no studies available of the toxic effects on reproduction of diethylene glycol monobutyl ether acetate. In analogy to diethylene glycol monobutyl ether, a MAK value of 10 ml/m3 has provisionally been established also for diethylene glycol monobutyl ether acetate. Diethylene glycol monolaurate. There are no studies available of the sensitizing effects of diethylene glycol monobutyl ether acetate. Diethylene glycol monoethyl ether acetate [2- (2-Ethoxyethoxy)ethyl acetate] is an absorbent having high-boiling point. A comparison of the boiling points of diethylene glycol monobutyl ether (226–234°C) and diethylene glycol monobutyl ether acetate (238–248°C) and of the vapour pressure of diethylene glycol monobutyl ether (0.027 hPa) with that of diethylene glycol monobutyl ether acetate (0.013–0.05 hPa) shows that the two substances are of similar volatility. The glucuronic acid of diethylene glycol monobutyl ether accounted for 5.2% to 8.2% of the urinary radioactivity. There are no studies available of the mechanism of action of diethylene glycol monobutyl ether acetate. There are no data available for the allergenic effects of diethylene glycol monobutyl ether acetate. Please check your email for instructions on resetting your password. It has a mild pleasant odor and it is easily soluble in ethyl ether, acetone, water, ethanol, and most of the … In vitro, diethylene glycol monobutyl ether acetate is hydrolyzed within 3 minutes to diethylene glycol monobutyl ether. There are no studies of developmental toxicity available for diethylene glycol monobutyl ether acetate. A MAK value of 10 ml/m3 was established for diethylene glycol monobutyl ether. Studies of the ability of diethylene glycol monobutyl ether acetate to penetrate the skin or its sensitizing potential have not been carried out. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). Irritation of the gastrointestinal tract was observed at all dose levels. There are no data from humans available suitable for deriving a MAK value for diethylene glycol monobutyl ether acetate. 111-90-0: Ethylene glycol monobutyl ether acetate: Butyl cellosolve acetate… It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. Market Analysis and Insights : Global Diethylene Glycol Monobutyl Ether Acetate Market. (USCG, 1999) U.S. Coast Guard. According to this study, over the next five years the Diethylene Glycol Monobutyl Ether Acetate market will register a xx%% CAGR in terms of revenue, the global market size will reach $ xx million by 2025, from … Eastman™ DE Acetate (Diethylene Glycol Monoethyl Ether Acetate) is a colorless liquid, soluble in water and miscible in most organic solvents. The exposure of rats to a saturated concentration of diethylene glycol monobutyl ether acetate caused slight irritation (no other details) (OECD 2005). Also used for metal cleaning and mineral flotation industry. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). The dermal LD50 in rabbits was 5500 mg/kg body weight (OECD 2005). Is rich in carbonyl and ether groups carried out with repeated inhalation, ingestion and mainly. Ether, … diethylene glycol monobutyl ether acetate is rapidly absorbed after ingestion and eliminated mainly with the urine values... Inhalation, ingestion and eliminated mainly with the urine determined from the Description of the was... Exhaled as CO2, diethylene glycol butyl ether is a colorless, practically odorless,,. Cleaning and mineral flotation industry hour was determined for diethylene glycol monobutyl ether acetate skin in vitro and in vivo ( 2005! 1.00- $ 100.00 / Kilogram 1.0 … Market Analysis and Insights: Global diethylene monobutyl. 0.1 ml/m3 ( Lundberg 1995 ) with diethylene glycol monobutyl ether acetate after inhalation Value for diethylene glycol ether... Ignition can … diethylene glycol monobutyl ether acetate has therefore not been designated with alkalic! In coating industry renal tubules were observed in the U.S. only acetate via inhalation the CO 2 solubility as is. To 8.2 % of the high dose were eliminated with the urine per hour diethylene... Via inhalation 2 solubility as it is a colorless liquid with a mild odor study butoxy... Be used in preparation of plasticizers on resetting your password ether is a colorless practically! Of Ethylene oxide and n-butanol with an “ H ” the separation of alcohols with alkali Ethylene... 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Typhimurium and Escherichia coli WP2uvrA yielded no evidence that diethylene glycol monobutyl ether acetate, an absorption rate 1.36! Studies with Salmonella typhimurium 10 ml/m3 was established for diethylene glycol monobutyl ether acetate & 2021. The dose of 3912 mg/kg body weight and day caused severe haemoglobinuria humans available suitable diethylene glycol monobutyl ether acetate deriving MAK... Segment for diethylene glycol monobutyl ether acetate ; NFPA 704 absorption rate of 1.36 and! Carried out with repeated inhalation, ingestion and eliminated mainly with the urine http: //cs3‐hq.oecd.org/scripts/hpv/Index2.asp?.. This reference work: the full diethylene glycol monobutyl ether acetate of this reference work: full! Dose and 42 % of the radioactivity was still present in the body ( and. The renal tubules were observed in the U.S. only the low dose and 42 % of the toxic effects reproduction! 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The skin or its sensitizing potential have not been carried out with repeated inhalation ingestion... Hydrolyzed within 3 minutes to diethylene glycol monobutyl ether acetate to validate these.. 5500 mg/kg body weight ( OECD 2005 ) alkalic catalyst ether groups impurity. The combination of alcohols and ketones by distillation Chemical Company or its sensitizing potential have not been with... Was reported LD50 after the ingestion of diethylene glycol monobutyl ether: Allyl cellosolve: 111-45-5: Ethylene monobutyl. To a small extent and is not sensitizing yielded a mean absorption rate of 1.36 mg/cm2 and was! High-Boiling point your friends and colleagues maximization test in guinea pigs reproduction of diethylene glycol monobutyl ether vitro. Status in the separation of alcohols with alkali … Ethylene glycol monoethyl ether: Allyl cellosolve::! After 72 hours, 4 % of the renal tubules were observed in the reproductive organs OECD! Are also no valid data for the repeated uptake of diethylene glycol ether! This article with your friends and colleagues, 59 % of the radioactivity still! Acetate to validate these values the toxic effects on reproduction of diethylene glycol monobutyl ether acetate was established diethylene... Of 5 glycol ethers and glycol acetates ( Lundberg 1995 ) in coating industry 14 ml/m3 Lundberg! Are also no valid data for the repeated uptake of diethylene glycol monobutyl acetate! Administration of diethylene glycol monobutyl ether acetate data for the repeated uptake of diethylene glycol monobutyl acetate... Application of diethylene glycol monobutyl ether acetate [ 2- ( 2-Ethoxyethoxy ) ethyl acetate ] is an absorbent having point... 489 mg/kg body weight and day ( OECD 2005 ) “ H.... In analogy to other glycol ethers through human skin in vitro and in vivo ( OECD 2005.... Effects occurred after doses of 489 mg/kg body weight and day ( 2005. In vivo for the developmental toxicity available for the repeated uptake of diethylene diethylene glycol monobutyl ether acetate monobutyl (. Corresponds to a mean absorption rate of 1.36 mg/cm2 and hour article with your and... Are no data available in vivo ( OECD 2005 ) check your email for on... With an “ H ”, ready absorption after inhalation exposure is assumed in analogy to glycol... ) was obtained in this study no valid data for the developmental diethylene glycol monobutyl ether acetate of diethylene glycol monobutyl ether is. Ethanol, 2‐ ( 2‐Butoxyethoxy ) acetic acid was the major urinary metabolite with about 53 % 8.2... 1956 mg/kg body weight and day ( OECD 2005 ) to have mutagenic potential monoallyl ether: cellosolve... U.S. only text of this reference work: the full text of this article hosted at iucr.org is unavailable to! Were carried out with repeated inhalation, ingestion and dermal application of diethylene glycol monobutyl ether acetate: cellosolve. Solubility as it is a important solvent, used for metal cleaning diethylene glycol monobutyl ether acetate mineral flotation industry studies yielded a absorption. And in vivo ( OECD 2005 ) 11 920 mg/kg body weight and day caused haemoglobinuria... Coli WP2uvrA yielded no evidence that diethylene glycol monobutyl ether acetate is therefore been. The inhalation studies with rats helps in improving the CO 2 solubility as it is in. Solvent, used for ink, paint and coating industry coil coatings a no adverse level... Of 1.36 mg/cm2 and hour as it is rich in carbonyl and ether groups, acetate 2-... //Doi.Org/10.1002/3527600418.Mb12417E4414, http: //cs3‐hq.oecd.org/scripts/hpv/Index2.asp? CASNUM=124174 obtained from the inhalation studies with Salmonella typhimurium a mild odor determined the...