More details: Systematic name. malathion Nummer i Chemical Abstracts (CAS-nr.) Malathion used as a fumigant was not associated with increased cancer risk. A racemate comprising equimolar amounts of (R) and (S)-malathion. The resultant phosphoester group is strongly bound to the cholinesterase, and irreversibly deactivates the enzyme which leads to rapid build-up of acetylcholine at the synapse.[11]. Upon uptake into the target organism, it binds irreversibly to the serine residue in the active catalytic site of the cholinesterase enzyme. Molecular Formula C 8 14 C 2 H 19 O 6 PS 2; Average mass 334.343 Da; Monoisotopic mass 334.042542 Da; ChemSpider ID 68023218 - Non-standard isotope. [27][28], Although current EPA regulations do not require amphibian testing, a 2008 study done by the University of Pittsburgh found that "cocktails of contaminants", which are frequently found in nature, were lethal to leopard frog tadpoles. Malathion is a pesticide that is widely used in agriculture, residential landscaping, public recreation areas, and in public health pest control programs such as mosquito eradication. Malathion is flammable. Malathion is classified by US EPA as having "suggestive evidence of carcinogenicity". Malathion (R,S)-diethyl-2-[(dimethoxyphosphorothioyl)sulfanyl]butanedioate is a chiral organophosphorus compound used widely as pesticide for suppression of harmful insects such as … In insects, Malathion works by binding irreversibly to an enzyme produced in the nervous system that transmits signals between nerves, thus overwhelming nerves with signals resulting in death. Beilstein/REAXYS Number 1714358 . Patients using this agent should not be exposed to heat sources when it is applied, such as blow dryers, cigarettes, or cooking flames. (ed.). Malathion is classified by US EPA as having "suggestive evidence of carcinogenicity". [29], Diethyl 2-[(dimethoxyphosphorothioyl)sulfanyl]butanedioate, 2-(Dimethoxyphosphinothioylthio) butanedioic acid diethyl ester, InChI=1S/C10H19O6PS2/c1-5-15-9(11)7-8(10(12)16-6-2)19-17(18,13-3)14-4/h8H,5-7H2,1-4H3, InChI=1/C10H19O6PS2/c1-5-15-9(11)7-8(10(12)16-6-2)19-17(18,13-3)14-4/h8H,5-7H2,1-4H3, Except where otherwise noted, data are given for materials in their, Tomlin, C.D.S. In jurisdictions which spray malathion for pest control, it is often recommended to keep windows closed and air conditioners turned off while spraying is taking place, in an attempt to minimize entry of malathion into the closed environment of residential homes. [5] In the US, it is the most commonly used organophosphate insecticide. In the US, it is the most commonly used organophosphate insecticide. Malathion is an organophosphate parasympathomimetic which binds irreversibly to cholinesterase. Malathion is a pesticide that is widely used in agriculture, residential landscaping, public recreation areas, and in public health pest control programs such as mosquito eradication. Malathion is a pesticide that is widely used in agriculture, residential landscaping, public recreation areas, and in public health pest control programs such as mosquito eradication. Malathion (R,S)-diethyl-2- [ (dimethoxyphosphorothioyl)sulfanyl]butanedioate is a chiral organophosphorus compound used widely as pesticide for suppression of harmful insects such as … [6], A malathion mixture with corn syrup was used in the 1980s in Australia and California to combat the Mediterranean fruit fly. It is well known that in biological systems (R)-malathion is the active enantiomer, therefore a sustainable approach could be the use of … Upon uptake into the target organism, it binds irreversibly to the serine residue in the active catalytic site of the cholinesterase enzyme. [26], A May 2010 study found that in a representative sample of US children, those with higher levels of organophosphate pesticide metabolites in their urine were more likely to have attention-deficit/hyperactivity disorder, but no causal relationship was established. Malathion in low doses (0.5% preparations) is used as a treatment for: Preparations include Derbac-M, Prioderm, Quellada-M[16] and Ovide. Malathion present in untreated water is converted to malaoxon during the chlorination phase of water treatment, so malathion should not be used in waters that may be used as a source for drinking water, or any upstream waters. Jump to main ... (dimethoxyphosphorothioyl)sulfanyl](2,3-14 C 2)butanedioate. Position of India in World Agriculture. Pure malathion is a colorless liquid, and technical-grade malathion, which contains >90% malathion and impurities in a solvent, is a brownish-yellow liquid that smells like garlic. It was discovered that poor work practices had resulted in excessive direct skin contact with isomalathion contained in the malathion solutions. The source code for the WIKI 2 extension is being checked by specialists of the Mozilla Foundation, Google, and Apple. Malathion is an organophosphate insecticide which acts as an acetylcholinesterase inhibitor. aerial malathion {diethyl 2-[(dimethoxyphosphorothioyl) sulfanyl]butanedioate} applications on blueberry (Vaccinium corymbosum. Between 1993 and 1997, as part of the Agricultural Health Study, researchers surveyed 19,717 pesticide applicators about their past pesticide exposures and health histories and no clear association between malathion exposure and cancer was reported. [27] Each 10-fold increase in urinary concentration of organophosphate metabolites was associated with a 55% to 72% increase in the odds of ADHD. Cropped area-wise pesticide share of major Indian crops. It is cleared from the body quickly, in three to five days.[20]. Malathion in low doses (0.5% preparations) is used as a treatment for: Preparations include Derbac-M, Prioderm, Quellada-M[16] and Ovide. [21] Acute exposure to extremely high levels of malathion will cause body-wide symptoms whose intensity will be dependent on the severity of exposure. malathion: ChEBI ID CHEBI:6651: Definition A racemate comprising equimolar amounts of (R) and (S)-malathion. They found that a combination of five widely used insecticides (carbaryl, chlorpyrifos, diazinon, endosulfan, and malathion) in concentrations far below the limits set by the EPA killed 99% of leopard frog tadpoles. Malathion is flammable. Malathion blocks the enzyme acetylcholinesterase which in turns prevents the nervous system from working properly. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Tomlin, C.D.S. [24] It is capable of inhibiting carboxyesterase enzymes in those exposed to it. (ed.). Malathion present in untreated water is converted to malaoxon during the chlorination phase of water treatment, so malathion should not be used in waters that may be used as a source for drinking water, or any upstream waters. The resultant phosphoester group is strongly bound to the cholinesterase, and irreversibly deactivates the enzyme which leads to rapid build-up of acetylcholine at the synapse.[11]. Implementation of good work practices, and the cessation of use of malathion contaminated with isomalathion led to the cessation of poisoning cases. Malathion was sprayed over a 1,400 sq mi (3,600 km2) area to control the flies.[23]. diethyl 2-[(dimethoxyphosphorothioyl) sulfanyl]butanedioate Diethyl mercaptosuccinate S-ester with O,O-dimethylphosphorodithioate Diethyl mercaptosuccinate, O,O-dimethyl dithiophosphate, s-ester [9][10], Malathion is an acetylcholinesterase inhibitor, a diverse family of chemicals. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites. In the US, it is the most commonly used organophosphate insecticide. Malathion is an insecticide of relatively low human toxicity; however, a 2010 study has shown that children with higher levels of organophosphate pesticide metabolites in their urine are more likely to have attention deficit hyperactivity disorder. [26], A May 2010 study found that in a representative sample of US children, those with higher levels of organophosphate pesticide metabolites in their urine were more likely to have attention-deficit/hyperactivity disorder, but no causal relationship was established. Sept 2007. Malathion, diethyl 2-[(dimethoxyphosphorothioyl)sulfanyl]butanedioate, is an organophosphate used to control insect pests. That's it. According to the United States Environmental Protection Agency there is currently no reliable information on adverse health effects of chronic exposure to malathion. The compound is chiral but is used as a racemate. Malathion diacid PESTANAL ®, analytical standard Synonym: 2-[(Dimethoxyphosphorothioyl) sulfanyl] succinic acid, O,O-Dimethyl S-(1,2-dicarboxyethyl) phosphorodithioate, Malathiondicarboxylic acid CAS Number 1190-28-9. Between 1993 and 1997, as part of the Agricultural Health Study, researchers surveyed 19,717 pesticide applicators about their past pesticide exposures and health histories and no clear association between malathion exposure and cancer was reported. Workplace Signs - minimum requirements & signs on containers and pipes . [21] Acute exposure to extremely high levels of malathion will cause body-wide symptoms whose intensity will be dependent on the severity of exposure. BACKGROUND: Malathion (R,S)-diethyl-2-[(dimethoxyphosphorothioyl)sulfanyl]butanedioate is a chiral organophosphorus compound used widely as pesticide for suppression of harmful insects such as mosquitoes. In 1981, B. T. Collins,[22] director of the California Conservation Corps, publicly swallowed a mouthful of dilute malathion solution to demonstrate its safety following an outbreak of Mediterranean fruit flies in California. Interactive Neurobehavioral Toxicity of Diazinon, Malathion, and Ethoprop to Juvenile Coho Salmon Cathy A. Laetz,*,† David H. Baldwin,† Vincent Hebert,‡ John D. Stark,§ and Nathaniel L. Scholz† †Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, 2725 Montlake Boulevard E., Seattle, Washington 98112, United States We have created a browser extension. Molecular Weight 274.25 . The study was the first investigation on children's neurodevelopment to be conducted in a group with no particular pesticide exposure. 10 MDCA: (2RS)-2-[(dimethoxyphosphorothioyl)sulfanyl]butanedioic acid Peer review of the pesticide risk assessment of the active substance malathion EFSA Scientific Report (2009) 333, 4-118 Most symptoms tend to resolve within several weeks. United States Environmental Protection Agency, National Institute for Occupational Safety and Health, "Malathion Exposure and the Incidence of Cancer in the Agricultural Health Study", "Insect Control - Public Works - City of Winnipeg", "Acetylcholinesterase Inhibitors: Pharmacology and Toxicology", "Guidelines for the diagnosis and treatment of pediculosis capitis (head lice) in children and adults 2008", "Reregistration Eligibility Decision for Malathion", "Study links pesticide to ADHD in children", "US Department of Health and Human Services: Agency for Toxic Substances and Disease Registry - Medical Management Guidelines for Malathion", "California Death Index, 1940-1997 [Database Online]", Reregistration Eligibility Decision for Malathion (Revised), "Attention-Deficit/Hyperactivity Disorder and Urinary Metabolites of Organophosphate Pesticides", "Organophosphate Pesticides Linked to ADHD", "Low Concentrations Of Pesticides Can Become Toxic Mixture For Amphibians", Malathion Technical Fact Sheet - National Pesticide Information Center, Malathion General Fact Sheet - National Pesticide Information Center, Malathion Pesticide Information Profile - Extension Toxicology Network, CDC - NIOSH Pocket Guide to Chemical Hazards, Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium bromide), 2-Ethoxycarbonyl-1-methylvinyl cyclohexyl methylphosphonate, Muscarinic acetylcholine receptor modulators, Nicotinic acetylcholine receptor modulators, 2008 United States salmonellosis outbreak, 2017–18 South African listeriosis outbreak, 2018 Australian rockmelon listeriosis outbreak, Spanish Agency for Food Safety and Nutrition, 156 to 157 °C (313 to 315 °F; 429 to 430 K) at 0.7 mmHg, Soluble in ethanol and acetone; very soluble in ethyl ether, 163 °C; 325 °F; 436 K (greater than), Srpskohrvatski / српскохрватски, Many of the other AChE inhibitors listed above. 121-75-5 EU-nummer (EINECS-nr.) It is quite volatile and has a low potential for leaching to groundwater. 204-497-7 ... Navn i Chemical Abstracts diethyl [(dimethoxyphosphinothioyl)thio]butanedioate IUPAC-navn diethyl (dimethoxythiophosphorylthio)succinate eller S-1,2-bis(ethoxycarbonyl)ethyl O,O-dimethyl phosphorodithioate Molekylestruktur: Kemisk familie: Navn: Kilde : Organophosphorus insekticider … In the USSR, it was known as carbophos, in New Zealand and Australia as maldison and in South Africa as mercaptothion. According to the United States Environmental Protection Agency there is currently no reliable information on adverse health effects of chronic exposure to malathion. It is moderately soluble in water and readily soluible in many organic solvents. [25] This classification was based on the occurrence of liver tumors at excessive doses in mice and female rats and the presence of rare oral and nasal tumors in rats that occurred following exposure to very large doses. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites. Would you like Wikipedia to always look as professional and up-to-date? Malathion is produced by the addition of dimethyl dithiophosphoric acid to diethyl maleate or diethyl fumarate. Malathion is an insecticide approved for use in the EU and in many other countries. Washington, DC: American Chemical Society., 1995., p. 80. Chemical name: Malathion (diethyl 2 - [(dimethoxyphosphorothioyl) sulfanyl] butanedioate) Experimental conditions: 16 scans British National Formulary 54th Ed. Malathion is classified by the IARC as probable carcinogen (group 2A). Patients using this agent should not be exposed to heat sources when it is applied, such as blow dryers, cigarettes, or cooking flames. [27][28], Although current EPA regulations do not require amphibian testing, a 2008 study done by the University of Pittsburgh found that "cocktails of contaminants", which are frequently found in nature, were lethal to leopard frog tadpoles. Usage of pesticides in India( state wise) Malathion is a pesticide that is widely used in agriculture, residential landscaping, public recreation areas, and in public health pest control programs such as mosquito eradication. United States Environmental Protection Agency, National Institute for Occupational Safety and Health, "Malathion Exposure and the Incidence of Cancer in the Agricultural Health Study", "Insect Control - Public Works - City of Winnipeg", "Acetylcholinesterase Inhibitors: Pharmacology and Toxicology", "Guidelines for the diagnosis and treatment of pediculosis capitis (head lice) in children and adults 2008", "Reregistration Eligibility Decision for Malathion", "Study links pesticide to ADHD in children", "US Department of Health and Human Services: Agency for Toxic Substances and Disease Registry - Medical Management Guidelines for Malathion", "California Death Index, 1940-1997 [Database Online]", Reregistration Eligibility Decision for Malathion (Revised), "Attention-Deficit/Hyperactivity Disorder and Urinary Metabolites of Organophosphate Pesticides", "Organophosphate Pesticides Linked to ADHD", "Low Concentrations Of Pesticides Can Become Toxic Mixture For Amphibians", Malathion Technical Fact Sheet - National Pesticide Information Center, Malathion General Fact Sheet - National Pesticide Information Center, Malathion Pesticide Information Profile - Extension Toxicology Network, CDC - NIOSH Pocket Guide to Chemical Hazards, Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium bromide), 2-Ethoxycarbonyl-1-methylvinyl cyclohexyl methylphosphonate, Muscarinic acetylcholine receptor modulators, Nicotinic acetylcholine receptor modulators, 2008 United States salmonellosis outbreak, 2017–18 South African listeriosis outbreak, 2018 Australian rockmelon listeriosis outbreak, Spanish Agency for Food Safety and Nutrition, https://en.wikipedia.org/w/index.php?title=Malathion&oldid=998666614, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Articles with unsourced statements from August 2016, Articles with specifically marked weasel-worded phrases from August 2016, Creative Commons Attribution-ShareAlike License, 156 to 157 °C (313 to 315 °F; 429 to 430 K) at 0.7 mmHg, Soluble in ethanol and acetone; very soluble in ethyl ether, Many of the other AChE inhibitors listed above, This page was last edited on 6 January 2021, at 13:21. In the USSR, it was known as carbophos, in New Zealand and Australia as maldison and in South Africa as mercaptothion. I use WIKI 2 every day and almost forgot how the original Wikipedia looks like. [19] Indoor spillage of malathion can thus be more poisonous than expected, as malathion breaks down in a confined space into the more toxic malaoxon. [8] Malathion was used over the last couple of decades on a regular basis during summer months to kill mosquitoes, but homeowners were allowed to exempt their properties if they chose. Last modification occurred on 7/28/2015 1:25:16 PM. Diethyl 2-[(dimethoxyphosphorothioyl)sulfanyl]butanedioate, 2-(Dimethoxyphosphinothioylthio) butanedioic acid diethyl ester, InChI=1S/C10H19O6PS2/c1-5-15-9(11)7-8(10(12)16-6-2)19-17(18,13-3)14-4/h8H,5-7H2,1-4H3, InChI=1/C10H19O6PS2/c1-5-15-9(11)7-8(10(12)16-6-2)19-17(18,13-3)14-4/h8H,5-7H2,1-4H3, Except where otherwise noted, data are given for materials in their. Diethyl-2-[(dimethoxyphosphorothioyl)sulfanyl]butandioat Organoderm EINECS 204-497-7 carbophos Malathion S-1,2-bis(ethoxycarbonyl)ethyl O,O-dimethyl phosphorodithioate S-Ester with O,O-Dimethyl Phosphorothioate Researchers conducted a study involving participants from six Canadian provinces and found that exposure to organophosphates as a group and malathion alone was associated with non-Hodgkin's lymphoma. It was discovered that poor work practices had resulted in excessive direct skin contact with isomalathion contained in the malathion solutions. In 1976, numerous malaria workers in Pakistan were poisoned by isomalathion, a contaminant that may be present in some preparations of malathion. To install click the Add extension button. In the US, it is the most commonly used organophosphate insecticide. [27] Each 10-fold increase in urinary concentration of organophosphate metabolites was associated with a 55% to 72% increase in the odds of ADHD. It is cleared from the body quickly, in three to five days.[20]. [9][10], Malathion is an acetylcholinesterase inhibitor, a diverse family of chemicals. In jurisdictions which spray malathion for pest control, it is often recommended to keep windows closed and air conditioners turned off while spraying is taking place, in an attempt to minimize entry of malathion into the closed environment of residential homes. Implementation of good work practices, and the cessation of use of malathion contaminated with isomalathion led to the cessation of poisoning cases. Congratulations on this excellent venture… what a great idea! Symptoms include skin and eye irritation, cramps, nausea, diarrhea, excessive sweating, seizures and even death. Drift from fields with extensive dense woody riparian vegetation was compared with drift from fields with no dense woody riparian vegetation. [18] In studies of the effects of long-term exposure to oral ingestion of malaoxon in rats, malaoxon has been shown to be 61 times more toxic than malathion,[18] and malaoxon is 1,000 times more potent than malathion in terms of its acetylcholinesterase inhibition. [5] In the US, it is the most commonly used organophosphate insecticide. Malathion is a pesticide that is widely used in agriculture, residential landscaping, public recreation areas, and in public health pest control programs such as mosquito eradication. The study was the first investigation on children's neurodevelopment to be conducted in a group with no particular pesticide exposure. [6], A malathion mixture with corn syrup was used in the 1980s in Australia and California to combat the Mediterranean fruit fly. [8] Malathion was used over the last couple of decades on a regular basis during summer months to kill mosquitoes, but homeowners were allowed to exempt their properties if they chose. Washington, DC: American Chemical Society., 1995., p. 80. Malathion was sprayed over a 1,400 sq mi (3,600 km2) area to control the flies.[23]. Most symptoms tend to resolve within several weeks. The compound is chiral but is used as a racemate. Sept 2007. You could also do it yourself at any point in time. In 1981, B. T. Collins,[22] director of the California Conservation Corps, publicly swallowed a mouthful of dilute malathion solution to demonstrate its safety following an outbreak of Mediterranean fruit flies in California. [17], Malathion is of low toxicity; however, absorption or ingestion into the human body readily results in its metabolism to malaoxon, which is substantially more toxic. Malathion is not usually persistent in soil or water systems. [7] In Canada and the US starting in the early 2000s, malathion was sprayed in many cities to combat west Nile virus. Malathion is classified by the IARC as probable carcinogen (group 2A). malathion (ISO); 1,2-bis(ethoxycarbonyl)ethyl O, O-dimethyl phosphorodithioate . [18] In studies of the effects of long-term exposure to oral ingestion of malaoxon in rats, malaoxon has been shown to be 61 times more toxic than malathion,[18] and malaoxon is 1,000 times more potent than malathion in terms of its acetylcholinesterase inhibition. Symptoms include skin and eye irritation, cramps, nausea, diarrhea, excessive sweating, seizures and even death. IUPAC Standard InChIKey: JXSJBGJIGXNWCI-UHFFFAOYSA-N; CAS Registry Number: 121-75-5; Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file The 3d structure may be viewed using Java or Javascript. Malathion is the most popular organophosphate insecticide. Empirical Formula (Hill Notation) C 6 H 11 O 6 PS 2. [24] It is capable of inhibiting carboxyesterase enzymes in those exposed to it. The Pesticide Manual - World Compendium, 11th ed., British Crop Protection Council, Surrey, England 1997, p. 755, Hansch, C., Leo, A., D. Hoekman. L.) farms with fields adjacent to streams or ditches were monitored. malathion (ISO); 1,2-bis(ethoxycarbonyl)ethyl O, O-dimethyl phosphorodithioate [containing ≤ 0,03 % isomalathion] CAD - Chemical Agents Directive, Art. It is well known that in biological systems (R)-malathion is the active enantiomer, therefore a sustainable approach could be the use of only the biologically active enantiomer. BACKGROUND: Malathion (R,S)-diethyl-2-[(dimethoxyphosphorothioyl)sulfanyl]butanedioate is a chiral organophosphorus compound used widely as pesticide for suppression of harmful insects such as mosquitoes. SCOPE OF ACCREDITATION Printable version Note: Not all of the columns of the scope of accreditation displayed include data. 114 mass spectra in 1 spectral trees are available online for the compound Malathion. Jump to main content Jump to site nav Home It will enhance any encyclopedic page you visit with the magic of the WIKI 2 technology. We,China MALATHION 121-75-5 Suppliers and China MALATHION 121-75-5 Manufacturers, provide MALATHION 121-75-5 product and the products related with China MALATHION 121-75-5 - taisongchem The Pesticide Manual - World Compendium, 11th ed., British Crop Protection Council, Surrey, England 1997, p. 755, Hansch, C., Leo, A., D. Hoekman. Synonyms: exact_synonym: rac-diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate : related_synonym: [citation needed] Today, Winnipeg is the only major city in Canada with an ongoing malathion adult-mosquito-control program. They found that a combination of five widely used insecticides (carbaryl, chlorpyrifos, diazinon, endosulfan, and malathion) in concentrations far below the limits set by the EPA killed 99% of leopard frog tadpoles.[29]. mzCloud ‒ Free Online Mass Spectrometry Database Malathion is an insecticide that does not occur naturally. [19] Indoor spillage of malathion can thus be more poisonous than expected, as malathion breaks down in a confined space into the more toxic malaoxon. Malathion is produced by the addition of dimethyl dithiophosphoric acid to diethyl maleate or diethyl fumarate. The only data displayed is that deemed relevant and necessary for the clear description of the activities and services covered by the scope of accreditation. Structure, properties, spectra, suppliers and links for: Diethyl (2R)-2-[(dimethoxyphosphorothioyl)sulfanyl]succinate. [7] In Canada and the US starting in the early 2000s, malathion was sprayed in many cities to combat west Nile virus. Structure, properties, spectra, suppliers and links for: Diethyl 2-[(dimethoxyphosphorothioyl)sulfanyl](2,3- 14 C 2 )butanedioate. diethyl 2-[(dimethoxyphosphorothioyl)sulfanyl]butanedioate - chemical information, properties, structures, articles, patents and more chemical data. Malathion is an organophosphate insecticide which acts as an acetylcholinesterase inhibitor. [17], Malathion is of low toxicity; however, absorption or ingestion into the human body readily results in its metabolism to malaoxon, which is substantially more toxic. diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate - chemical information, properties, structures, articles, patents and more chemical data. [25] This classification was based on the occurrence of liver tumors at excessive doses in mice and female rats and the presence of rare oral and nasal tumors in rats that occurred following exposure to very large doses. In 1976, numerous malaria workers in Pakistan were poisoned by isomalathion, a contaminant that may be present in some preparations of malathion. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. [citation needed] Today, Winnipeg is the only major city in Canada with an ongoing malathion adult-mosquito-control program. British National Formulary 54th Ed. It is used outdoors to control a wide variety of insects in agricultural settings and around homes. Malathion used as a fumigant was not associated with increased cancer risk. It will enhance any encyclopedic page you visit with the magic of the WIKI 2 technology. ] [ 10 ], malathion is an acetylcholinesterase inhibitor, a contaminant that may present... Malathion blocks the enzyme acetylcholinesterase which in turns prevents the nervous system from working properly a family! 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